abstract：:Porphyromonas gingivalis is highly implicated in the pathogenesis of periodontitis, which is characterized by the destruction of periodontal connective tissues and the supporting alveolar bone. Receptor Activator of NF-kappaB Ligand (RANKL) stimulates bone resorption, whereas osteoprotegerin (OPG) blocks its action, a...

journal_title：Microbial pathogenesis

authors： Belibasakis GN,Bostanci N,Hashim A,Johansson A,Aduse-Opoku J,Curtis MA,Hughes FJ

更新日期：2007-07-01 00:00:00

abstract：:The IrgA homolog adhesin (Iha) is an adherence-conferring outer membrane protein of Escherichia coli associated with enterohemorrhagic and uropathogenic strains. Here, we used primer extension analysis to identify iha promoters in O157:H7 and uropathogenic E. coli strains. Transcriptional fusions demonstrated that iha...

journal_title：Microbial pathogenesis

authors： Rashid RA,Tarr PI,Moseley SL

更新日期：2006-12-01 00:00:00

abstract：:The present study characterizes immune cell populations in mice chronically infected with Salmonella. Mice were characterized as chronically infected based on persistently high titers of Salmonella-reactive immunoglobulins in the serum >6 months after a single oral dose of S. enterica serovar Typhimurium. These mice h...

journal_title：Microbial pathogenesis

authors： Johansson C,Ingman M,Jo Wick M

更新日期：2006-08-01 00:00:00

abstract：:Establishment of pulmonary Mycobacterium tuberculosis infection requires evasion of host innate defenses. In the lung alveoli, epithelial cells naturally resist uptake by the inhaled bacilli while macrophages patrol the epithelial surface and phagocytose foreign microbes. Alveolar microvascular endothelial cells, howe...

journal_title：Microbial pathogenesis

authors： Mehta PK,Karls RK,White EH,Ades EW,Quinn FD

更新日期：2006-08-01 00:00:00

abstract：:Salmonella pathogenicity island 2 (SPI2) encodes a type III secretion system (TTSS) necessary for bacterial survival and replication in intracellular environment of host cells. SPI2 genes are transcribed preferentially after Salmonella enters the host cells. Transcriptional regulation of ssaG encoding the component of...

journal_title：Microbial pathogenesis

authors： Lim S,Kim B,Choi HS,Lee Y,Ryu S

更新日期：2006-07-01 00:00:00

abstract：:Opportunistic infections, due to disease-related immunosuppression, constitute the major cause of death in American visceral leishmaniasis (AVL). Sera from these patients (AVL sera) non-specifically inhibit the in vitro proliferative response of normal human lymphocytes to lectins or antigens. In the present work, the...

journal_title：Microbial pathogenesis

authors： Soares NM,Ferraz TP,Nascimento EG,Carvalho EM,Pontes-de-Carvalho L

更新日期：2006-06-01 00:00:00

abstract：:The involvement of nitric oxide (NO) in host defense and cytoprotective functions in murine salmonellosis has been reported. Salmonella mutants with the altered sigma factor RpoS (sigmaS) are less virulent and are susceptible to various stresses. This study investigated the role of the rpoS gene of Salmonella enterica...

journal_title：Microbial pathogenesis

authors： Alam MS,Zaki MH,Yoshitake J,Akuta T,Ezaki T,Akaike T

更新日期：2006-03-01 00:00:00

abstract：:Animal studies with Candida albicans have provided models for understanding fungal virulence and antifungal drug development. To non-invasively monitor long-term Candida murine infections, clinical isolates were stably transformed with a codon-optimized luciferase gene to constitutively express luciferase. Chronic sys...

journal_title：Microbial pathogenesis

authors： Doyle TC,Nawotka KA,Kawahara CB,Francis KP,Contag PR

更新日期：2006-02-01 00:00:00

abstract：:Pneumocystis infection leads to a life threatening pneumonia in susceptible individuals. While depletion or dysfunction of CD4+T cells is a key determinant of susceptibility to Pneumocystis, the host response that leads to resolution of infection or lung injury is less well understood. We had previously shown that mic...

journal_title：Microbial pathogenesis

authors： Rose CM,Kimzey SL,Green JM

更新日期：2006-01-01 00:00:00

abstract：:Identification of mycobacterial adhesins is needed to understand better the pathogenesis of tuberculosis and to develop new strategies to fight this infection. In this work, THP-1 monocytic cells were incubated with Mycobacterium tuberculosis culture filtrate proteins labelled with biotin and a dominant 19-kDa adhesin...

journal_title：Microbial pathogenesis

authors： Diaz-Silvestre H,Espinosa-Cueto P,Sanchez-Gonzalez A,Esparza-Ceron MA,Pereira-Suarez AL,Bernal-Fernandez G,Espitia C,Mancilla R

更新日期：2005-09-01 00:00:00

abstract：:Group B streptococci (GBS) are opportunistic human pathogens that cause infection and invasive disease in newborns, pregnant women and non-pregnant adults. The internalization of GBS into eukaryotic cells occurs in an actin-microfilament dependent process. The objective of our study was to understand what host cell an...

journal_title：Microbial pathogenesis

authors： Burnham CA,Shokoples SE,Tyrrell GJ

更新日期：2005-05-01 00:00:00

abstract：:Human leishmaniasis is a spectral disease that includes asymptomatic self-resolving infection, localized skin lesions, and progressive visceral leishmaniasis. With some overlap, visceral and cutaneous leishmaniasis are usually caused by different species of Leishmania. This review focuses on host responses to infectio...

journal_title：Microbial pathogenesis

authors： Wilson ME,Jeronimo SM,Pearson RD

更新日期：2005-04-01 00:00:00

abstract：:The role of Porphyromonas gingivalis cysteine proteinases (gingipains) in the evasion of host cell-mediated immunity has not been fully determined. In this study, modulation by gingipains of accessory and co-stimulatory molecule expression on human CD4(+) T cells was evaluated. Arg-gingipain rather than Lys-gingipain ...

journal_title：Microbial pathogenesis

authors： Yun PL,Decarlo AA,Chapple CC,Collyer CA,Hunter N

更新日期：2005-02-01 00:00:00

abstract：:Carbohydrate analyses of whole-spore extracts have confirmed the presence of rhamnose in the spore of the fully virulent Ames strain of Bacillus anthracis. A gene cluster containing loci with high homology to the rhamnose biosynthetic genes, rmlACBD, was identified within the B. anthracis chromosome. The first gene of...

journal_title：Microbial pathogenesis

authors： Bozue JA,Parthasarathy N,Phillips LR,Cote CK,Fellows PF,Mendelson I,Shafferman A,Friedlander AM

更新日期：2005-01-01 00:00:00

abstract：:Influenza A virus infection plays a significant role in the pathogenesis of Streptococcus pneumoniae-induced acute otitis media in children. An understanding of how influenza A virus modulates host cellular responses is critically important in efforts to explore the molecular mechanisms of this synergism. We used micr...

journal_title：Microbial pathogenesis

authors： Tong HH,Long JP,Li D,DeMaria TF

更新日期：2004-10-01 00:00:00

abstract：:Up to 28-fold differences in vacA expression in Helicobacter pylori strains grown in vitro were demonstrated by real time quantitative RT-PCR. These large differences in expression were unrelated to putative -35 and -10 motifs or to other untranslated sequences upstream of the ATG start site. The lack of correlation b...

journal_title：Microbial pathogenesis

authors： Ayala G,Chihu L,Perales G,Fierros-Zárate G,Hansen LM,Solnick JV,Sánchez J

更新日期：2004-09-01 00:00:00

abstract：:The current study determined the ability of Francisella novicida to act as a live vaccine against the much more virulent, but closely related pathogen, Francisella tularensis. Live attenuated strains of the latter are effective vaccines against human tularemia. However, the molecular cause of their attenuation remains...

journal_title：Microbial pathogenesis

authors： Shen H,Chen W,Conlan JW

更新日期：2004-08-01 00:00:00

abstract：:Yersinia pestis, the etiologic agent of plague is a highly invasive organism being able to invade non-phagocytic epithelial cells. Its plasminogen activator (Pla), encoded by the pPCP1 plasmid plays a pivotal role in internalisation of bacteria by HeLa cells. The aim of this study was to analyse the intracellular sign...

journal_title：Microbial pathogenesis

authors： Benedek O,Nagy G,Emody L

更新日期：2004-07-01 00:00:00

abstract：:Most strains of Salmonella enterica subspecies enterica serotype typhimurium (S. typhimurium) naturally harbour a virulence plasmid which carries the salmonella plasmid virulence (spv) genes. However, isolates belonging to certain phage types are generally found without the plasmid. We have utilized a self-transferabl...

journal_title：Microbial pathogenesis

authors： Olsen JE,Brown DJ,Thomsen LE,Platt DJ,Chadfield MS

更新日期：2004-06-01 00:00:00

abstract：:YopM is a type III secretion effector from Yersinia which contributes to pathogenicity but whose action still remains unclear. It is an acidic, leucine-rich repeats (LRR) containing protein which migrates to the nucleus of target cells in spite of the fact that it does not contain any classical nuclear localization si...

journal_title：Microbial pathogenesis

authors： Benabdillah R,Mota LJ,Lützelschwab S,Demoinet E,Cornelis GR

更新日期：2004-05-01 00:00:00

abstract：:Molecular-genetic properties of classical biotype Vibrio cholerae strains that caused the Asiatic cholera outbreak in 1942 in Russia have been investigated for the first time. Being characterized by high-level production of cholera toxin and toxin-coregulated adhesion pili both of which are the major virulence factors...

journal_title：Microbial pathogenesis

authors： Smirnova NI,Cheldyshova NB,Zadnova SP,Kutyrev VV

更新日期：2004-03-01 00:00:00

abstract：:In mice, nitric oxide (NO) production by inducible NO synthase (iNOS), is a component of the control of Brucella infection. In humans, the involvement of iNOS in infection is still a matter of debate. Based on in vitro experiments, it was recently postulated that in humans, Brucella infection tends to become chronic b...

journal_title：Microbial pathogenesis

authors： Gross A,Bertholet S,Mauel J,Dornand J

更新日期：2004-02-01 00:00:00

abstract：:Orientia tsutsugamushi, an obligate intracellular bacterium, is the causative agent of scrub typhus which is histopathologically characterized by inflammatory manifestations, indicating that rickettsiae induce mechanisms that amplify the inflammatory response. To understand the pathogenesis of scrub typhus, we examine...

journal_title：Microbial pathogenesis

authors： Koh YS,Yun JH,Seong SY,Choi MS,Kim IS

更新日期：2004-01-01 00:00:00

abstract：:Recent studies based on sequence divergence in the ospC gene have identified limited subpopulations of B. burgdorferi associated with invasive human disease. Spirochetes with certain OspC types never cause human disease, while some others cause local infection at the primary skin site but do not hematogenously dissemi...

journal_title：Microbial pathogenesis

authors： Xu Y,Bruno JF,Luft BJ

更新日期：2003-12-01 00:00:00

abstract：:The Sm-like protein Hfq has been implicated in the regulation of sigmaS-dependent and sigmaS-independent genes in E. coli and in the regulation of virulence factors in both, Yersinia enterocolitica and Brucella abortus. Here, we have studied the effect of Hfq on virulence and stress response of Pseudomonas aeruginosa ...

journal_title：Microbial pathogenesis

authors： Sonnleitner E,Hagens S,Rosenau F,Wilhelm S,Habel A,Jäger KE,Bläsi U

更新日期：2003-11-01 00:00:00

abstract：:Tuberculosis is the leading infectious disease in the world. Mycobacterium tuberculosis, the causal agent of this disease, invades macrophages and can replicate inside them. Because invasion of macrophages is a critical step for establishing a mycobacterial infection, there is much interest in understanding the mechan...

journal_title：Microbial pathogenesis

authors： Velasco-Velázquez MA,Barrera D,González-Arenas A,Rosales C,Agramonte-Hevia J

更新日期：2003-09-01 00:00:00

abstract：:Acanthamoeba are free-living, harmless organisms, however, given the opportunity and the appropriate conditions, they can cause painful, sight-threatening as well as fatal infections and, thus, are considered opportunistic pathogens. Acanthamoeba infections have become increasingly important in the past few years due ...

journal_title：Microbial pathogenesis

authors： Khan NA

更新日期：2003-06-01 00:00:00

abstract：:Mannheimia(Pasteurella)haemolytica serotype 1 is the primary causative agent responsible for bovine pneumonic mannheimiosis, also known as shipping fever in cattle. The bacterium produces a variety of virulence factors, foremost of which is the exotoxic leukotoxin. The leukotoxin is a calcium-dependent cytolysin that ...

journal_title：Microbial pathogenesis

authors： Thumbikat P,Briggs RE,Kannan MS,Maheswaran SK

更新日期：2003-05-01 00:00:00

abstract：:Oropharyngeal candidiasis is a frequent opportunistic infection associated with immunocompromised hosts. Candida albicans is the principal species responsible for this infection. Production of interleukin-8 (IL-8), by oral epithelial cells can be expected to play a major role in the recruitment and activation of profe...

journal_title：Microbial pathogenesis

authors： Dongari-Bagtzoglou A,Kashleva H

更新日期：2003-04-01 00:00:00

abstract：:Chlamydia pneumoniae is associated with several chronic human diseases, including chronic obstructive pulmonary disease and atherosclerotic cardiovascular disease. During chronic disease, organisms are believed to exist in a persistent phase that is not well understood at the genetic level. Long-term in vitro continuo...

journal_title：Microbial pathogenesis

authors： Hogan RJ,Mathews SA,Kutlin A,Hammerschlag MR,Timms P

更新日期：2003-01-01 00:00:00

abstract：:Clinical isolates of Pseudomonas aeruginosa are either invasive or cytotoxic towards mammalian epithelial cells, endothelial cells, and macrophages. Invasion requires host cell actin cytoskeleton function, and ExsA-regulated proteins of P. aeruginosa that inhibit invasion (ExoS and ExoT) can disrupt the cytoskeleton. ...

journal_title：Microbial pathogenesis

authors： Evans DJ,Kuo TC,Kwong M,Van R,Fleiszig SM

更新日期：2002-09-01 00:00:00

abstract：:Siderophores are low molecular weight molecules that allow bacteria to acquire iron from host cell proteins. 2,3-dihydroxybenzoic acid (DHBA) is the only known siderophore produced by the intracellular pathogen Brucella abortus. Here its role in virulence was assessed by evaluating the ability of a mutant with a disru...

journal_title：Microbial pathogenesis

authors： Parent MA,Bellaire BH,Murphy EA,Roop RM 2nd,Elzer PH,Baldwin CL

更新日期：2002-05-01 00:00:00

abstract：:It has been shown that N-linked high mannose type oligosaccharides competitively inhibits attachment to and infectivity of chlamydiae in HeLa cells. To further study whether mannose moieties are involved in the infectivity of chlamydiae, the susceptibility of mannose-receptor negative J774A and positive J774E mouse ma...

journal_title：Microbial pathogenesis

authors： Kuo CC,Puolakkainen M,Lin TM,Witte M,Campbell LA

更新日期：2002-01-01 00:00:00

abstract：:Three coagulase-negative Staphylococcus species (CNS) (Staphylococcus epidermidis, Staphylococcus xylosus and Staphylococcus hyicus), from the milk of cows with mastitis, were used to evaluate adherence to and internalization by bovine mammary epithelial cells, and to investigate involvement of host cell signal transd...

journal_title：Microbial pathogenesis

authors： Almeida RA,Oliver SP

更新日期：2001-11-01 00:00:00

abstract：:Infections with the obligate intracellular bacterium Chlamydia trachomatis are characterized by avoidance of fusion between chlamydia-containing endosomes and lysosomes, bacterial persistence and development of post-infectious sequelae. In this report we show that C. trachomatis induces apoptosis in McCoy and HeLa cel...

journal_title：Microbial pathogenesis

authors： Schöier J,Ollinger K,Kvarnström M,Söderlund G,Kihlström E

更新日期：2001-10-01 00:00:00

abstract：:Protein D, having a glycerol-3-phosphodiester phosphodiesterase activity, is found at the surface of all Haemophilus influenzae strains and is a possible virulence factor. In the present study, the involvement of protein D in the entry of NTHi into human monocytic cells is reported. Primary monocytes and the monocytic...

journal_title：Microbial pathogenesis

authors： Ahrén IL,Janson H,Forsgren A,Riesbeck K

更新日期：2001-09-01 00:00:00

abstract：:Murine gammaherpesvirus 72 (MHV-72) is a virus of wild rodents and serves as a convenient small animal model to understand the pathogenesis of Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV8) infection. In laboratory mice MHV-72 causes an acute infection of lung epithelial cells and establishes the latency in B...

journal_title：Microbial pathogenesis

authors： Raslova H,Berebbi M,Rajcani J,Sarasin A,Matis J,Kudelova M

更新日期：2001-08-01 00:00:00

abstract：:A common feature of many chlamydial infections is that they are often asymptomatic and may persist for long periods of time if left untreated. In addition to the well recognized lytic stage of the chlamydial developmental cycle, evidence is now emerging to support a persistent phase in the cycle in which the reticulat...

journal_title：Microbial pathogenesis

authors： Mathews S,George C,Flegg C,Stenzel D,Timms P

更新日期：2001-06-01 00:00:00

abstract：:Little is known about the virulence factors of Burkholderia mallei, the etiologic agent of glanders. We employed subtractive hybridization to identify genetic determinants present in B. mallei but not in Burkholderia thailandensis, a non-pathogenic soil microbe. Three subtractive hybridization products were mapped to ...

journal_title：Microbial pathogenesis

authors： DeShazer D,Waag DM,Fritz DL,Woods DE

更新日期：2001-05-01 00:00:00

abstract：:Chlamydia pneumoniae has been linked to atherosclerotic heart disease. However, there is a limited knowledge by which C. pneumoniae gain access to atheromatous lesions. The adhesion of C. pneumoniae -infected circulatory component(s) to endothelium and smooth muscle cells represents the first step in an inflammatory r...

journal_title：Microbial pathogenesis

authors： Kaul R,Wenman WM

更新日期：2001-03-01 00:00:00